Jess finds himself in Liberty, Texas, in a running gunfight between himself and the crazed killer, Sully Hurst. Hurst gets lucky and escapes on his horse. Jess has a bit more trouble in Liberty before leaving town and going after Hurst again.
While searching for his next hunt, he arrives in Segundo, Texas, where he gets into a wild shootout in the saloon.
While in Bream, Texas, he learns that Ansel Maclin has escaped from the state penitentiary, killing one of the prison guards in the process. He decides to hunt Maclin down, but he soon finds out that this quest will have to wait.
He gets a message from the schoolmarm, Martha Heller, in Harrison. He drops everything and heads her way.
Jess leaves Donger, Texas, and his good friend, John Bodine, to hunt for the ruthless and vicious killer, George Meyer, who was last seen in the town of Chastain.
While there, Jess sees a man bullying a young boy by the man of Johnny, but before Jess reaches them, the 150-pound timber wolf, Shadow, shows up out of nowhere to help.
When Jess continues the hunt for Meyer, Shadow joins in and accompanies him.
Jess wonders if Shadow is just along for the company…or if he knows something that Jess doesn’t.
He soon discovers that to be the case, when he is asked to hunt down three ruthless killers.
Jess leaves Opal, Texas, and travels to the town of Donger to find the next man on his hunt list, Dom Preston. In the process, Jess takes yet another bullet, which leads him to meet Dr. Sam Vaughn, a middle-aged woman with impressive skills as a doctor.
His wound is minor and he leaves Donger to take Preston’s body to the town of Waveland to turn him into the law there. He finds out about a stagecoach robbery by three outlaws. They kidnap Dr. Vaughn and force her into helping one of them who was wounded in the robbery.
One of the men who were killed in the robbery, happened to be a very wealthy man. His wife, Lizzy Draper, hires Jess to hunt down the three men who murdered her husband.
John Bodine is assigned to help Jess and the hunt becomes dangerous with Jess’s enemies trying to catch the bounty and kill him in the process.
But Jess isn’t one to go down without a fight.
Jess leaves Bend, Texas, to head to Gardner, where a gang of outlaws has been terrorizing the town. The gunslinger and gambler, Cheyenne, offers his help to return a huge favor.
John Bodine gets called into service and is sent to Gardner, Texas, to assist Jess. He arrives first and is captured and locked up in the town jail.
When Jess arrives, he rescues Bodine. Then, Jess, Bodine, and Cheyenne confront the outlaws terrorizing Gardner. Lead flies and men die before the battle is over.
After the deadly gunfight, Jess splits off from the other two, on the hunt for Ruben Straight. Along the way, he decides to pursue two more wanted killers…one by one.
Jess is on the hunt for the murderous Theo Connor. He leaves Wooster, Texas, and heads to Henryville, where Connor was last seen. Along the way, Jess runs into the infamous gunslinger, Cheyenne.
When Jess arrives in Henryville, Connor is not there, but Cheyenne is. When Jess checks in at the telegraph office, he sees a threatening message regarding Cheyenne from Slim Cordell, a ruthless killer who has never yet been caught. It seems Cordell wants Cheyenne dead.
Jess convinces Cheyenne to ride with him until they can find out where Cordell and his gang of thugs are. He finally catches up to Connor in the town of Ruben and Jess kills him. Before it’s over though, six other outlaws lie dead at the hands of Jess and Cheyenne.
The twosome head to Barstow next, where one of Cordell’s men attempts to kill Cheyenne from a distance. Jess, not one to run, sets up an ambush for Cordell and his men. He ends up killing one of them, turning the tables on Cordell and his gang.
But Cordell is not one to give up easily. He wants Cheyenne dead more than he wants to live, which makes him a very dangerous man.