Jess is back on the job, hunting the next killer on his list, Mick Barton. His hunt takes him to the town of Carlisle, but before he gets there, he finds a couple murdered along the trail next to their wagon.
When he takes the bodies into Carlisle, he discovers that Arthur Meeks and Elliot Wrigley were the murderers. He also learns that they left Carlisle on the same southern trail that Mick Barton had used to leave. He begins his search for all three of them.
After successfully catching the three, he takes the bodies to the county sheriff in the town of Bradford. On his way, he discovers a stagecoach that has been robbed. The only person who survived was a young woman named Amanda.
Jess immediately takes a liking to her and brings her to Bradford so the doctor can treat her bullet wound. He puts her up in the hotel in Bradford and helps to take care of her. He soon finds out that she was a mail-order bride on her way to marry a rich rancher outside of El Paso.
While recovering from her wound, Amanda is able to sketch likenesses of the two men who robbed the stagecoach. As soon as Jess sees them, he knows exactly who they are: Larry Thompson and Henry Wadsworth.
He goes on the hunt for them, promising Amanda that he will come back after he catches them.
Jess is on the hunt for Alan Bush, which takes him to the town of Frost, Texas. After killing Bush, he shoots another wanted man who happens to show up in Frost before Jess leaves.
When he takes the bodies to the town of Burnham to turn in to the marshal there, he discovers that the marshal is out looking for a prisoner who escaped from his jail.
Marshall Dan Lester convinces Jess to track down his escaped prisoner for him. After successfully tracking down the prisoner, Jess is back on the hunt for more killers who are on his list.
Then he receives a message from United States Marshal Frank Reedy in Stratton, Texas, informing him of news he never wanted to hear.
The one ruthless killer that Jess let go because he’d lost all memory of his previous life has regained his memory and returned to his old killing ways.
Jess is not willing to make that mistake again. An old friend comes to help him rectify the situation.
Jess is on the trail of the next man on his hunt list, Stacey Kern, when he comes across a strange custom-built and enclosed wagon. The men escorting the wagon try to hire Jess as one of their guards.
He doesn’t accept the job but it seems his travels crisscross the wagon on its way to Houston, Texas. Along the way, he encounters two other outlaws who aren’t wanted dead or alive, but are obviously interested in what’s in the wagon.
He stops the two outlaws from ambushing the wagon, but then they meet up with two other men who have some information about the wagon and what’s being transported inside it.
The four outlaws team up together and attempt another ambush. Jess shows up during the middle of the fight.
Bullets fly and men die.
Jess discovers that Wildcat has been hunted and wounded by the vicious Eastwood gang. She sends a wire message asking for his help along with John Bodine’s. Jess drops what he’s doing and rides directly to Stratton, Texas, to pick up Bodine before heading to Hadley, Texas, where Wildcat is secretly holed up in a hotel.
The huge timber wolf, Shadow, is still with Jess when he reaches Stratton. The next morning, Jess, Bodine and Shadow head for Hadley to help Wildcat.
When they begin their hunt for the Eastwood gang, they discover that the killers have ridden out in three different directions.
The three of them, along with the help of the wolf, work together on one of the longest manhunts to track down every one of the Eastwood gang and put them where they belong… in the grave.
Jess heads to the town of McFadden in search of the killer Tom Winston. When he finally kills Winston, he takes the body to the town of Sulphur Springs to turn in to the law.
When he arrives, he discovers that the town Marshall, Ron Wagner, had been knocked out during a jailbreak. Sam Cartwright, a vicious killer, escaped with the help of his old partner, Burt Clark.
Wagner and Jess leave Sulphur Springs on the hunt for Clark and Cartwright, but when they do, they find that they also have the huge timber wolf, Shadow, joining them.
They finally catch Clark and Cartwright. Jess kills Cartwright and they take Clark back to Sulphur Springs to await trial.
Jess and Shadow leave Sulphur Springs and head to the town of Crafton in search of another killer by the name of Butch Russell.
Along the way he finds a family who were travelling in a covered wagon. The mother and father were murdered in the front seat. Shadow finds the daughter out in the field. She had been shot and left for dead.
They stay at the wagon long enough for the daughter, Dana, to be able to travel to Crafton to see a doctor.
Jess ends up taking her with him on the hunt for the two killers who murdered her parents and left her for dead.