Jess is on the hunt for the murderous Theo Connor. He leaves Wooster, Texas, and heads to Henryville, where Connor was last seen. Along the way, Jess runs into the infamous gunslinger, Cheyenne.
When Jess arrives in Henryville, Connor is not there, but Cheyenne is. When Jess checks in at the telegraph office, he sees a threatening message regarding Cheyenne from Slim Cordell, a ruthless killer who has never yet been caught. It seems Cordell wants Cheyenne dead.
Jess convinces Cheyenne to ride with him until they can find out where Cordell and his gang of thugs are. He finally catches up to Connor in the town of Ruben and Jess kills him. Before it’s over though, six other outlaws lie dead at the hands of Jess and Cheyenne.
The twosome head to Barstow next, where one of Cordell’s men attempts to kill Cheyenne from a distance. Jess, not one to run, sets up an ambush for Cordell and his men. He ends up killing one of them, turning the tables on Cordell and his gang.
But Cordell is not one to give up easily. He wants Cheyenne dead more than he wants to live, which makes him a very dangerous man.
After leaving the town of Woodward, Texas, and his secret sister, Beth Sloan, Jess is back on the hunt for Arnie Boseman, who has continued to escape his grasp.
His hunt takes him to Webster, Texas, but he misses Boseman once more, and the killer has resumed his killing spree yet again.
While in Webster, the Texas Ranger whose wife was Arnie Boseman’s first kill shows up in town. He gives Jess no choice but to let him join the hunt. The Ranger, Terrance Whittle, is so grief-stricken that he becomes erratic, putting both their lives in danger.
Jess has to continue the hunt for Boseman, and at the same time keep the Ranger from doing something he’ll regret later. After finally sending Arnie Boseman to his grave, Jess receives a message from United States Marshal Frank Reedy. John Bodine was expected back in Stratton after helping Jess in Woodward but never showed up.
Jess drops everything he’s doing and follows his back trail. He finds Bodine, who had been ambushed and left for dead but now John can’t remember anything.
Jess hunts for the men he thinks are responsible with the help of the wolf named Shadow.
Jess is hunting the dangerous killer, Murry Lander, which takes him to Hillsboro, Texas. When he arrives, he discovers that two men have just gunned down the town mayor.
He tracks the two killers to the town of Mason and discovers that Lander has also been there. Meanwhile, another bounty hunter shows up looking for Lander.
A young girl named Sissy arrives on the stagecoach. Jess finds himself saddled with her and her quest to find her brother. If that isn’t enough to deal with, he ends up helping another woman, Marybeth, who has been held against her will for years.
He feels obligated to help Sissy find her brother and help Marybeth find a new life, but there’s a chance he might have to kill Sissy’s brother when he finds him.
Jess leaves Calcutta and heads to the town of Menard on the hunt for Derik Bartholin. While there, he runs into two rather strange-acting men. Feeling confident that they robbed the bank in the town of Tecumseh, he follows them out of town and arrests them.
After Jess brings them to Menard and locks them up, a sharp attorney gets the charges dropped. Jess is stung by the law he swears to uphold. Frustrated, he heads back out to hunt for Bartholin.
He returns to Menard and finds two sisters, Betty and Susan Arnold, badly beaten by Susan’s husband, Mack Burden. He promises to hunt down Burden and bring him to justice. Then, he gets an assignment from United States Marshal Frank Reedy. He is to find two escapees who were being transported to the Huntsville State Penitentiary and deliver them to the nearest jail…alive.
Along the way, he runs into another professional bounty hunter who is after the same two escapees. Jess is concerned that he’ll end up hauling Burden to Menard alive at the same time that he hauls the two escapees to jail. The idea of tending not just one, but three criminals stretches his patience to the limit.
After splitting up from the young bounty hunter, John Smith, Jess is on the hunt for Malcomb Ruel, which takes him to Muncie, Texas. While in Muncie, he discovers that since passing through the town of Kearny they hired a marshal, but he was gunned down hours after he took the job. He then hunts the two men who killed the marshal and returns to Kearny to let them know the men responsible have paid the price.
While there, he receives a request from United States Marshal Frank Reedy, telling him to meet him and John Bodine in the town of Calcutta, where five men have robbed the bank, killed two deputies and wounded the marshal, an old friend of both Bodine and Reedy.
While in Calcutta, Wildcat shows up looking for the elusive killer, Noah Cain. Jess promises to help Wildcat catch Cain if she helps them chase down the five robbers.
Jess, Reedy, Bodine and Wildcat team up together, and they hunt down the robbers. With these four on your trail, your odds of escaping aren’t good. The hunt begins. Lead flies and men die, but will justice be done in the end?